PROF. ISABELLA SCREPANTI SHORT CV

Doctor Screpanti is, since 1999, Professor of General Pathology in the Medical School of the Faculty of Medicine and Surgery of the University "La Sapienza" of Rome, Italy.

The main steps of her curriculum vitae are as follows:

- 1977: Graduation cum laude in Medicine and Surgery. Faculty of Medicine and Surgery, Catholic University of Rome, Italy.
- 1980: post-Graduation cum laude in Pediatrics. Faculty of Medicine and Surgery, Catholic University of Rome, Italy.
- 1980-84: Investigator, Collége de France, C.N.R.S., Foundation for Hormone Research, Paris, France.
- 1985-86: Visiting scientist, Laboratory of Experimental Immunology, FCRF, National Cancer Institute, Frederick, MD USA.
- 1984-89: Investigator, Department of Experimental Medicine, Faculty of Medicine and Surgery, University of Rome, Italy.
- 1990-93: Medical Assistant of Biothecnology Section of National Institut for Cancer Research (IST Genova), Italy.
- 1993-99: Associate Professor of General Pathology in the Medical School of the Faculty of Medicine and Surgery of the University "La Sapienza" of Rome, Italy.

RESEARCH FIELDS

1. Analysis of cellular and molecular mechanisms involved in T cell differentiation through the generation of in vivo and in vitro experimental models;
2. Characterization of the molecular events involved in T cell leukemogenesis, mainly focusing on generating transgenic mice useful to understand the role of deregulated Notch signaling in sustaining development and progression of T cell Acute Lymphoblastic Leukemia;
3. Identification of molecular markers of Lymphoid Leukemias, susceptible to become therapeutic targets

10 SELECTED PUBLICATIONS

1. Rosati E, Sabatini R, Rampino G, Tabilio A, Di Ianni M, Fettucciari K, Bartoli A, Coaccioli S, Screpanti I, Marconi P.
Constitutively activated Notch signaling is involved in survival and apoptosis resistance of B-CLL cells.
Blood. 2009 Jan 22;113(4):856-65. Epub 2008 Sep 16.

2. Bellavia D, Checquolo S, Campese AF, Felli MP, Gulino A, Screpanti I.
Notch3: from subtle structural differences to functional diversity.
Oncogene. 2008 Sep 1;27(38):5092-8.

3. Bellavia D, Mecarozzi M, Campese AF, Grazioli P, Talora C, Frati L, Gulino A, Screpanti I.
Notch3 and the Notch3-upregulated RNA-binding protein HuD regulate Ikaros alternative splicing.
EMBO J. 2007 Mar 21;26(6):1670-80. Epub 2007 Mar 1.

4. Vacca A, Felli MP, Palermo R, Di Mario G, Calce A, Di Giovine M, Frati L, Gulino A, Screpanti I.
Notch3 and pre-TCR interaction unveils distinct NF-kappaB pathways in T-cell development and leukemia.
EMBO J. 2006 Mar 8;25(5):1000-8. Epub 2006 Feb 23.

5. Talora C, Cialfi S, Oliviero C, Palermo R, Pascucci M, Frati L, Vacca A, Gulino A, Screpanti I.
Cross talk among Notch3, pre-TCR, and Tal1 in T-cell development and leukemogenesis.
Blood. 2006 Apr 15;107(8):3313-20. Epub 2005 Dec 20.

6. Felli MP, Vacca A, Calce A, Bellavia D, Campese AF, Grillo R, Di Giovine M, Checquolo S, Talora C, Palermo R, Di Mario G, Frati L, Gulino A, Screpanti I.
PKC theta mediates pre-TCR signaling and contributes to Notch3-induced T-cell leukemia.
Oncogene. 2005 Feb 3;24(6):992-1000.

7. Talora C, Campese AF, Bellavia D, Pascucci M, Checquolo S, Groppioni M, Frati L, von Boehmer H, Gulino A, Screpanti I.
Pre-TCR-triggered ERK signalling-dependent downregulation of E2A activity in Notch3-induced T-cell lymphoma.
EMBO Rep. 2003 Nov;4(11):1067-72. Epub 2003 Oct 17

8. Screpanti I, Bellavia D, Campese AF, Frati L, Gulino A.
Notch, a unifying target in T-cell acute lymphoblastic leukemia?
Trends Mol Med. 2003 Jan;9(1):30-5.

9. Bellavia D, Campese AF, Checquolo S, Balestri A, Biondi A, Cazzaniga G, Lendahl U, Fehling HJ, Hayday AC, Frati L, von Boehmer H, Gulino A, Screpanti I.
Combined expression of pTalpha and Notch3 in T cell leukemia identifies the requirement of preTCR for leukemogenesis.
Proc Natl Acad Sci U S A. 2002 Mar 19;99(6):3788-93.

10. Bellavia D, Campese AF, Alesse E, Vacca A, Felli MP, Balestri A, Stoppacciaro A, Tiveron C, Tatangelo L, Giovarelli M, Gaetano C, Ruco L, Hoffman ES, Hayday AC, Lendahl U, Frati L, Gulino A, Screpanti I.
Constitutive activation of NF-kappaB and T-cell leukemia/lymphoma in Notch3 transgenic mice.
EMBO J 2000 Jul 3;19(13):3337-48.